PoD-TPI: Probability-of-Decision Toxicity Probability Interval Design to Accelerate Phase I Trials
نویسندگان
چکیده
منابع مشابه
A modified toxicity probability interval method for dose-finding trials.
BACKGROUND Building on earlier work, the toxicity probability interval (TPI) method, we present a modified TPI (mTPI) design that is calibration-free for phase I trials. PURPOSE Our goal is to improve the trial conduct and provide more effective designs while maintaining the simplicity of the original TPI design. METHODS Like the TPI method, the mTPI consists of a practical dose-finding sch...
متن کاملModified toxicity probability interval design: a safer and more reliable method than the 3 + 3 design for practical phase I trials.
The 3 + 3 design is the most common choice among clinicians for phase I dose-escalation oncology trials. In recent reviews, more than 95% of phase I trials have been based on the 3 + 3 design. Given that it is intuitive and its implementation does not require a computer program, clinicians can conduct 3 + 3 dose escalations in practice with virtually no logistic cost, and trial protocols based ...
متن کاملDose-finding in phase I clinical trials based on toxicity probability intervals.
BACKGROUND Most phase I clinical trials conducted at the M. D. Anderson Cancer Center use the algorithmic 3 + 3 design, despite the availability of more advanced model-based designs such as the continual reassessment method. PURPOSE Through simple statistical modeling and computing, we develop a dose-finding design that can be easily understood and implemented by non-statisticians. METHODS ...
متن کاملA predictive probability design for phase II cancer clinical trials.
BACKGROUND Two- or three-stage designs are commonly used in phase II cancer clinical trials. These designs possess good frequentist properties and allow early termination of the trial when the interim data indicate that the experimental regimen is inefficacious. The rigid study design, however, can be difficult to follow exactly because the response has to be evaluated at prespecified fixed num...
متن کاملInterval-Valued Probability Measures
The purpose of this paper is propose a simple de nition of an interval-valued probability measure and to examine some of the implications of this de nition. This de nition provides a method for characterizing certain types of imprecise probabilities. We develop some properties of this de nition and propose a de nition of integration with respect to it. We show that this de nition is a generaliz...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Statistics in Biosciences
سال: 2019
ISSN: 1867-1764,1867-1772
DOI: 10.1007/s12561-019-09264-0